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3D Spheroids Propel Tumor Characterization.

Abstract
Determining the functions of cancer driver genes in cancer models to mimic in vivo tumors has been a significant challenge. In a recent study, Han et al. implemented large-scale clustered regularly interspaced short palindromic repeats (CRISPR) screening in 3D lung cancer spheroids, revealing advantages of 3D spheroids over 2D monolayers, wherein novel therapeutic targets were identified, such as carboxypeptidase D (CPD).
AuthorsShengli Li, Zhao Zhang, Leng Han
JournalTrends in cancer (Trends Cancer) Vol. 6 Issue 8 Pg. 622-624 (08 2020) ISSN: 2405-8025 [Electronic] United States
PMID32423684 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2020 Elsevier Inc. All rights reserved.
Topics
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Humans
  • Lung Neoplasms
  • Oncogenes

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