Liver cancer is a devastating disease for humans with poor prognosis. Although the survival rate of patients with
liver cancer has improved in the past decades, the recurrence and
metastasis of
liver cancer are still obstacles for us.
Inositol polyphosphate-5-phosphatase K (INPP5K) belongs to the family of
phosphoinositide 5-phosphatases (PI 5-phosphatases), which have been reported to be associated with cell migration, polarity, adhesion, and cell invasion, especially in
cancers. However, there have been few studies on the correlation of INPP5K and
liver cancer. In this study, we explored the prognostic significance of INPP5K in
liver cancer through bioinformatics analysis of data collected from The
Cancer Genome Atlas (TCGA) database. Chi-square and Fisher exact tests were used to evaluate the relationship between INPP5K expression and clinical characteristics. Our results showed that low INPP5K expression was correlated with poor outcomes in
liver cancer patients. Univariate and multivariate Cox analyses demonstrated that low INPP5K
mRNA expression played a significant role in shortening overall survival (OS) and relapse-free survival (RFS), which might serve as the useful
biomarker and prognostic factor for
liver cancer. In conclusion, low INPP5K
mRNA expression is an independent risk factor for poor prognosis in
liver cancer.