Abstract | BACKGROUND:
Iodine is a trace element whose adequate intakes are essential during gestation to promote the correct growth and development of the fetus. Historically, endemic goiter and cretinism affected northern regions of Algeria, and iodized salt was introduced in 1990. However, there has been no national study of iodine nutrition in Algeria since 1994. The aim of this study was to assess the iodine status and thyroid function of women of reproductive age (WRA) and pregnant women (PW) in northern Algeria. METHODS: RESULTS: The median UIC in WRA was 256 μg/L (IQR: 166-354 μg/L; n = 151) in Algiers and 253 μg/L (167-341 μg/L; n = 150) in Tizi-Ouzou. The median UIC for the PW in Algiers was 233 μg/L (IQR: 157-326 μg/L; n = 173).Thirty-five percent of WRA and 30% of PW had an UIC > 300 μg/L. Median TSH, FT4 and Tg concentrations were within reference ranges in all groups of women. Among PW, 72.7%, 75.4% and 75.5% in the first, second and third trimester were TPO-Ab+. Among TPO-Ab + PW in the first, second and third trimesters, 18.7%, 13% and 10.3% had subclinical hypothyroidism. CONCLUSION: In northern Algeria, median UICs in PW indicate iodine sufficiency, and in WRA indicate more than adequate intakes. About 75% of PW are TPO-Ab + and the prevalence of subclinical hypothyroidism is high. Monitoring and surveillance of iodine fortification programs is vital to avoid both iodine deficiency and excess. There is an urgent need for a comprehensive national iodine status survey including school-age children and other vulnerable population groups in Algeria.
|
Authors | Samira Akdader-Oudahmane, Zohra Hamouli-Saïd, Michael B Zimmermann, Hanane Kherrab, Said Azzoug, Djamila Meskine |
Journal | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
(J Trace Elem Med Biol)
Vol. 61
Pg. 126533
(Apr 29 2020)
ISSN: 1878-3252 [Electronic] Germany |
PMID | 32417633
(Publication Type: Journal Article)
|
Copyright | Copyright © 2020 Elsevier GmbH. All rights reserved. |