Abstract | AIM: METHODS: RESULTS: No association was found between the HLA alleles and NAFLD or NASH in a case-control setting. Nevertheless, among NAFLD patients, the frequency of HLA-DQB1*06 allele was significantly the lowest in NASH with significant fibrosis (10.4%) and approximately similar for NASH without significant fibrosis (22.9%) and NAFL (22.5%) (P = 0.004). It is noteworthy that the association remains significant after correction for multiple comparisons (Pc = 0.04). Multivariate analysis revealed that HLA-DQB1*06 allele is also associated with fibrosis score (P = 0.001); the result remains significant after correction for multiple comparisons. CONCLUSION:
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Authors | Hwa-Li Tan, Shamsul Mohd Zain, Hooi-Sian Eng, Zahurin Mohamed, Sanjiv Mahadeva, Wah-Kheong Chan, Peng-Choong Lau, Roma Choudhury Basu, Rosmawati Mohamed |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 50
Issue 8
Pg. 947-954
(Aug 2020)
ISSN: 1386-6346 [Print] Netherlands |
PMID | 32410320
(Publication Type: Journal Article)
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Copyright | © 2020 The Japan Society of Hepatology. |