The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.

Abstract

OBJECTIVE:

To investigate the clinical features of COVID-19 cases in Suzhou China. Biomarkers were screened out of hematological parameters for risk stratification.

METHOD:

Confirmed COVID-19 adult patients in Suzhou were included. The patient data was collected, and the results of laboratory examinations were compared between the mild/moderate and severe COVID-19 groups. A ROC was calculated to compare the diagnostic performance of candidate indexes, and dynamic levels of hematological indexes were compared between the two groups.

RESULT:

75 patients were enrolled, with a mean age of 46.6 ± 14 years, and 45 patients were male. All patients were classified into two groups: the mild/moderate group and the severe group. WBC, neutrophil to lymphocyte ratio (NLR), D-dimer, and fibrinogen levels of the severe group were significantly higher (P < 0.05) than the mild/moderate, and the lymphocyte was lower. The ROC test showed that the hematological parameters had a larger AUC than that of inflammatory factors. There was a significant difference in lymphocyte and fibrinogen levels between the two groups on day 1 (P < 0.05). However, NLR of the severe group was higher than the mild/moderate on days 1, 4 and 14 (P < 0.01), and so was D-dimer on days 1, 7 and 14 (P < 0.05).

CONCLUSION:

The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leukopenia, which were significantly different between the mild/moderate and severe COVID-19 groups. Furthermore, the dynamic change of NLR and D-dimer level can distinguish severe COVID-19 cases from the mild/moderate.

• Authors: Jianhong Fu, Jindan Kong, Wei Wang, Meiying Wu, Lin Yao, Zhaoyue Wang, Jun Jin, Depei Wu, Xin Yu
• Journal: Thrombosis research (Thromb Res) Vol. 192 Pg. 3-8 (08 2020) ISSN: 1879-2472 [Electronic] United States
• PMID: 32407937 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers
• Fibrin Fibrinogen Degradation Products
• fibrin fragment D

Topics

• Adult
• Aged
• Betacoronavirus (pathogenicity)
• Biomarkers (blood)
• COVID-19
• COVID-19 Testing
• China
• Clinical Laboratory Techniques
• Coronavirus Infections (blood, diagnosis, therapy, virology)
• Female
• Fibrin Fibrinogen Degradation Products (analysis)
• Host-Pathogen Interactions
• Humans
• Lymphocyte Count
• Lymphocytes
• Male
• Middle Aged
• Neutrophils
• Pandemics
• Pneumonia, Viral (blood, diagnosis, therapy, virology)
• Predictive Value of Tests
• Prognosis
• Reproducibility of Results
• Retrospective Studies
• SARS-CoV-2
• Severity of Illness Index
• Young Adult