Influence of dietary fiber on chronic kidney disease： Base on the gut-kidney axis theory.

Abstract

Chronic kidney disease (CKD) can result in alteration of intestinal flora and damage of intestinal barrier function. Intestinal dysbios is contributes to the generation of colon-derived uremic solutes and the translocation of bacteria and endotoxins from gut lumen into the bloodstream, subsequently increasing uremic toxicity and triggering systemic inflammation, which is related to CKD progression and many complications. Studies have revealed that dietary fiber can reduce uremic toxin levels and systemic inflammation in CKD through targeting the "gut-kidney axis". Dietary fiber seems to be a promising measure for CKD treatment.

• Authors: Xiaohui Xie, Siyuan Dai, Yanling Dai, Jianping Ning
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 45 Issue 2 Pg. 193-197 (Feb 28 2020) ISSN: 1672-7347 [Print] China
• Vernacular Title: 基于肠-肾轴理论浅析膳食纤维对慢性肾病的影响.
• PMID: 32386047 (Publication Type: Journal Article, Review)

Chemical References

• Dietary Fiber

Topics

• Dietary Fiber
• Gastrointestinal Microbiome
• Humans
• Inflammation
• Kidney
• Renal Insufficiency, Chronic