Abstract | BACKGROUND: METHODS: The study only selects clinical randomized controlled trials of vitamin D supplementation for T2DM combined with NAFLD. We will search each database from the built-in until July 2020. The English literature mainly searches Cochrane Library, Pubmed, EMBASE, and Web of Science. While the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Meanwhile, we will retrieve clinical trial registries and grey literature. Two researchers worked independently on literature selection, data extraction, and quality assessment. The dichotomous data is represented by relative risk (RR), and the continuous is expressed by mean difference (MD) or standard mean difference (SMD), eventually the data is synthesized using a fixed effect model (FEM) or a random effect model (REM) depending on the heterogeneity. The imaging markers of liver, biomarkers of hepatic steatosis, serological indexes of hepatic fibrosis, serum NAFLD liver fat score were evaluated as the main outcomes. While several secondary outcomes were also evaluated in this study. The statistical analysis of this meta-analysis was conducted by RevMan software version 5.3. RESULTS: This meta-analysis will further determine the beneficial efficacy of vitamin D supplementation for T2DM combined with NAFLD. CONCLUSION: This study determines the positive efficacy of vitamin D supplementation for diabetic patients with NAFLD.
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Authors | Shengju Wang, Baochao Cai, Xuke Han, Yang Gao, Xiaoran Zhang, Ruili Wang, Yuan Zhang, Qiu Chen |
Journal | Medicine
(Medicine (Baltimore))
Vol. 99
Issue 19
Pg. e20148
(May 2020)
ISSN: 1536-5964 [Electronic] United States |
PMID | 32384501
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Biomarkers
- Diabetes Mellitus, Type 2
(drug therapy, epidemiology)
- Dietary Supplements
- Humans
- Liver Function Tests
- Non-alcoholic Fatty Liver Disease
(drug therapy, epidemiology)
- Randomized Controlled Trials as Topic
- Research Design
- Vitamin D
(therapeutic use)
- Meta-Analysis as Topic
- Systematic Review as Topic
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