(-)-cis-Carveol, a Natural Compound, Improves β-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus.

Abstract

Alzheimer's disease (AD) could be considered a multifactorial neurodegenerative disorder characterized by the accumulation of the β-amyloid-peptide (Aβ) within the brain leading to cognitive deficits, oxidative stress, and neuroinflammation. The present work was carried out to investigate the neuroprotective effect of (-)-cis-carveol (1% and 3%, for 21 days) against the β-amyloid-peptide 1-42- (Aβ1-42-) induced AD. Twenty-five rats were divided into five groups (n = 5/group): the first group-control (sham-operated); the second group-Aβ1-42 (1 mM) that received donepezil treatment (5 mg/kg, as the positive reference drug in the Y-maze and the radial arm maze tests); the third group-Aβ1-42 (1 mM); the fourth and fifth groups-Aβ1-42 (1 mM) that received (-)-cis-carveol treatment groups (1% and 3%). The results of this study demonstrated that (-)-cis-carveol improved Aβ1-42-induced memory deficits examined by using Y-maze and radial arm maze in vivo tests. Also, the biochemical analyses of the hippocampus homogenates showed that (-)-cis-carveol reduced hippocampal oxidative stress caused by Aβ1-42. Our results suggested that the use of (-)-cis-carveol may be suitable for decreasing AD-related symptoms.

• Authors: Lucian Hritcu, Razvan Stefan Boiangiu, Mayara Castro de Morais, Damião Pergentino de Sousa
• Journal: BioMed research international (Biomed Res Int) Vol. 2020 Pg. 8082560 ( 2020) ISSN: 2314-6141 [Electronic] United States
• PMID: 32382574 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Lucian Hritcu et al.

Chemical References

• Amyloid beta-Peptides
• Cyclohexane Monoterpenes
• Neuroprotective Agents
• Peptide Fragments
• amyloid beta-protein (1-42)
• carveol

Topics

• Alzheimer Disease (drug therapy, metabolism, pathology, physiopathology)
• Amyloid beta-Peptides (metabolism)
• Animals
• Cyclohexane Monoterpenes (pharmacology)
• Hippocampus (metabolism, pathology, physiopathology)
• Male
• Memory Disorders (drug therapy, metabolism, pathology, physiopathology)
• Neuroprotective Agents (pharmacology)
• Oxidative Stress (drug effects)
• Peptide Fragments (metabolism)
• Rats
• Rats, Wistar