The use of plasma rich in growth factors (PRGF) in guided tissue regeneration and guided bone regeneration. A review of histological, immunohistochemical, histomorphometrical, radiological and clinical results in humans.

Abstract

BACKGROUND:

Modern surgeries have advanced toward personalized minimal-invasive treatments with a high rate of clinical healing that facilitates the regeneration of tissues. One of the leading approaches to deliver endogenous plasma- and platelet-derived growth factors is the plasma rich in growth factors (PRGF). This narrative review determines the effects of using PRGF in different oral surgical procedures including alveolar ridge augmentation, socket preservation, sinus floor augmentation and periodontal regeneration.

METHODS:

For this narrative review, a literature search was conducted using PubMed and Researchgate. A combination of the following text words was used to maximize search specificity and sensitivity: "platelet-rich plasma", "PRP", "PRGF", "Platelet-rich growth factor", "socket preservation", "Extraction", "infra-bony pockets", "sinus floor augmentation", "randomized clinical controlled trials", "Alveolar osteitis", "Periodontal regeneration", "guided bone regeneration", "guided tissue regeneration".

RESULTS:

Investigations have generally agreed that PRGF can promote and accelerate the healing process. PRGF optimizes the patient's quality of life by reducing pain, swelling and inflammation rate and also accelerates regeneration of soft tissue and bone tissue regeneration as well.

CONCLUSIONS:

There is increasing evidence to support the use of PRGF in oral surgical procedures in order to improve the healing processes of the oral soft and hard tissues.

• Authors: Önder Solakoglu, Guido Heydecke, Niusha Amiri, Eduardo Anitua
• Journal: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft (Ann Anat) Vol. 231 Pg. 151528 (Sep 2020) ISSN: 1618-0402 [Electronic] Germany
• PMID: 32376297 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.

Chemical References

• Intercellular Signaling Peptides and Proteins

Topics

• Bone Regeneration (physiology)
• Guided Tissue Regeneration (methods)
• Humans
• Intercellular Signaling Peptides and Proteins (administration & dosage, therapeutic use)
• Plasma (chemistry)
• Platelet-Rich Plasma (physiology)
• Postoperative Complications (prevention & control)
• Quality of Life
• Wound Healing (physiology)