Abstract |
Long noncoding RNA ( lncRNA) have emerged as crucial regulators for a myriad of biological processes, and perturbations in their cellular expression levels have often been associated with cancer pathogenesis. In this study, we identified AATBC (apoptosis-associated transcript in bladder cancer, LOC284837) as a novel lncRNA. AATBC was found to be highly expressed in nasopharyngeal carcinoma (NPC), and increased AATBC expression was associated with poor survival in patients with NPC. Furthermore, AATBC promoted migration and invasion of NPC cells in vitro, as well as metastasis in vivo. AATBC upregulated the expression of the desmosome-associated protein pinin (PNN) through miR-1237-3p sponging. In turn, PNN interacted with the epithelial-mesenchymal transition (EMT) activator ZEB1 and upregulated ZEB1 expression to promote EMT in NPC cells. Collectively, our results indicate that AATBC promotes NPC progression through the miR-1237-3p-PNN-ZEB1 axis. Our findings indicate AATBC as a potential prognostic biomarker or therapeutic target in NPC.
|
Authors | Ting Tang, Liting Yang, Yujian Cao, Maonan Wang, Shanshan Zhang, Zhaojian Gong, Fang Xiong, Yi He, Yujuan Zhou, Qianjin Liao, Bo Xiang, Ming Zhou, Can Guo, Xiaoling Li, Yong Li, Wei Xiong, Guiyuan Li, Zhaoyang Zeng |
Journal | Molecular oncology
(Mol Oncol)
Vol. 14
Issue 9
Pg. 2251-2270
(09 2020)
ISSN: 1878-0261 [Electronic] United States |
PMID | 32364663
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. |
Chemical References |
- AATBC long noncoding RNA, human
- Antigens, CD
- CDH1 protein, human
- Cadherins
- Cell Adhesion Molecules
- MIRN1237 microRNA, human
- MicroRNAs
- Nuclear Proteins
- PNN protein, human
- RNA, Long Noncoding
- ZEB1 protein, human
- Zinc Finger E-box-Binding Homeobox 1
|
Topics |
- Animals
- Antigens, CD
(genetics, metabolism)
- Cadherins
(genetics, metabolism)
- Cell Adhesion Molecules
(genetics, metabolism)
- Cell Line, Tumor
- Cell Movement
(genetics)
- Down-Regulation
(genetics)
- Epithelial-Mesenchymal Transition
(genetics)
- Gene Expression Regulation, Neoplastic
- Humans
- Mice, Nude
- MicroRNAs
(genetics, metabolism)
- Nasopharyngeal Carcinoma
(genetics, pathology)
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Nuclear Proteins
(genetics, metabolism)
- Prognosis
- Protein Binding
(genetics)
- RNA, Long Noncoding
(metabolism)
- Zinc Finger E-box-Binding Homeobox 1
(metabolism)
|