Malignant Ovarian Steroid Cell Tumor, Not Otherwise Specified, Causes Virilization in a 4-Year-Old Girl: A Case Report and Literature Review.

Abstract

We report a case of a 4-year-old girl with an ovarian steroid cell tumor, not otherwise specified (SCT-NOS). She was admitted to the hospital with progressing virilization and Cushing's syndrome, which included abnormality of the perineum, hirsutism, hypertrichosis, flushing of face, hoarseness, and weight gain. Blood testing showed a significantly increased testosterone level and slightly increased cortisol level. Computed tomography scan revealed an 8.0 × 5.0 × 5.0 cm tumor of the right ovary. The patient underwent right salpingo-oophorectomy, and pathological examination showed malignant potential. Three courses of bleomycin, etoposide, and cisplatin were administered as postoperative chemotherapy. After tumor resection, her testosterone decreased to undetectable levels. However, during the course of the treatment, the patient suffered from adrenal insufficiency resulting in the need for hydrocortisone replacement therapy. Although SCT-NOS in childhood are typically benign, pathological findings should be carefully observed for potential malignancy. In cases of cortisol-producing SCT-NOS, serum levels should be monitored, and hydrocortisone replacement therapy should be considered before resection.

• Authors: Takaharu Yoshimatsu, Kozo Nagai, Reiji Miyawaki, Kyoko Moritani, Kazuhiro Ohkubo, Jun Kuwabara, Kyosuke Tatsuta, Mie Kurata, Mana Fukushima, Riko Kitazawa, Junpei Hamada, Fumihiro Ochi, Minenori Eguchi-Ishimae, Hisamichi Tauchi, Mariko Eguchi
• Journal: Case reports in oncology (Case Rep Oncol) 2020 Jan-Apr Vol. 13 Issue 1 Pg. 358-364 ISSN: 1662-6575 [Print] Switzerland
• PMID: 32355490 (Publication Type: Case Reports)
• Copyright: Copyright © 2020 by S. Karger AG, Basel.