A randomized controlled trial of the effects of non-surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients.

Abstract

BACKGROUND:

Periodontitis significantly increases the risk of diabetic complications. This clinical trial investigated the effects of periodontal therapy on cardiac function in patients with type 2 diabetes mellitus (T2DM) and periodontitis.

MATERIALS AND METHODS:

Fifty-eight subjects with T2DM and periodontitis were randomly allocated to Treatment Group (n = 29) receiving non-surgical periodontal therapy, and Control Group (n = 29) having only oral hygiene instructions with delayed periodontal treatment until completion of this 6-month study. The left ventricle (LV) diastolic function was assessed by echocardiography with the tissue Doppler imaging index (E/e' ratio); and LV hypertrophy was evaluated by LV mass index (LVMI). Blood samples were collected for biochemical analysis.

RESULTS:

The intention-to-treat analysis showed that periodontal treatment significantly reduced the E/e' ratio by 1.66 (95% CI: -2.64 to -0.68, p < .01), along with marked improvement of periodontal conditions (p < .05). LVMI was not altered at the 6-month follow-up. The serum levels of N-terminal pro-B type natriuretic peptide (NT-proBNP) as a cardiac stress biomarker, C-reactive protein and interleukin-6 decreased numerically without reaching statistical significance.

CONCLUSION:

The present study provides the first evidence that non-surgical periodontal therapy may improve cardiac diastolic function in type 2 diabetic patients with periodontitis.

• Authors: Yi Wang, Hin Nam Liu, Zhe Zhen, George Pelekos, Mei Zhen Wu, Yan Chen, Maurizio Tonetti, Hung Fat Tse, Kai Hang Yiu, Lijian Jin
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 47 Issue 6 Pg. 726-736 (06 2020) ISSN: 1600-051X [Electronic] United States
• PMID: 32350903 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Peptide Fragments

Topics

• Diabetes Complications
• Diabetes Mellitus, Type 2 (complications, therapy)
• Echocardiography
• Humans
• Peptide Fragments
• Periodontitis
• Ventricular Function, Left