Evaluation of two commercial peach extracts for skin prick testing in the diagnosis of hypersensitivity to lipid transfer protein. A multicenter study.

Abstract

Summary:

The clinical usefulness of two commercial peach extracts for SPT (by Lofarma SpA and ALK-Abellò, respectively) was compared in a multicenter study carried out in Italy. Peach allergic patients were tested with the two extracts in parallel and underwent the detection of IgE specific for all three peach allergens currently available (Pru p1, Pru p3, and Pru p4, respectively). The two extracts were almost identical in terms of sensitivity and specificity, being able to detect virtually all patients sensitized to stable peach allergens (lipid transfer protein (LTP) and, presumably, peamaclein) but scoring negative in patients exclusively sensitive to labile allergens (either PR-10 and/or profilin). Thus, the two extracts represent an excellent tool to carry out a preliminary component-resolved diagnosis of peach allergy at the first patient visit.

• Authors: R Asero, A Aruanno, M Bresciani, I Brusca, M Carollo, L Cecchi, G Cortellini, G Deleonardi, A Farsi, E Ferrarini, G Gabrielli, A Ingrassia, M Mauro, F Murzilli, E Nucera, R Onida, E A Pastorello, E Pinter, A Rizzi, M Russello, C Sacerdoti, E Scala, G Scala, D Villalta, S Zampogna, S Amato, G Mistrello
• Journal: European annals of allergy and clinical immunology (Eur Ann Allergy Clin Immunol) Vol. 53 Issue 4 Pg. 168-170 (07 2021) ISSN: 1764-1489 [Print] Italy
• PMID: 32347686 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Allergens
• Antigens, Plant
• Carrier Proteins
• Plant Extracts
• Plant Proteins
• lipid transfer protein
• Immunoglobulin E

Topics

• Allergens (immunology)
• Antigens, Plant (analysis, immunology)
• Carrier Proteins
• Food Hypersensitivity (diagnosis, immunology)
• Humans
• Immunoglobulin E
• Plant Extracts (chemistry, immunology)
• Plant Proteins (analysis, immunology)
• Prunus persica
• Skin Tests (methods)