Different solid forms for optimizing route of administration of the herpes drug Pritelivir.

Abstract

Pritelivir (AIC316, BAY 57-1293) was discovered as a highly potent drug against herpes simplex viruses with a novel mode of action, i.e. inhibition of the viral helicase-primase. A side by side comparison of the oral form against Valtrex™ in patients with genital herpes, showed superiority in phase II testing for Pritelivir. A number of different solid forms have been generated for additional, e.g. systemic, or topical applications.

• Authors: Helga Ruebsamen-Schaeff, Helmut Buschmann
• Journal: MedChemComm (Medchemcomm) Vol. 10 Issue 11 Pg. 1867-1870 (Nov 01 2019) ISSN: 2040-2503 [Print] England
• PMID: 32346467 (Publication Type: Journal Article, Review)
• Copyright: This journal is © The Royal Society of Chemistry 2019.