Abstract |
The aim of this study is to observe the influence of Medication-Related Osteonecrosis of the Jaw (MRONJ) on the physical and mental conditions of cancer patients using a Quality of Life (QoL) questionnaire during regular dental practice measures. Twenty cancer patients (8 males and 12 females) with established MRONJ were enrolled in the "MoMax" ( Oral Medicine and Maxillofacial) project of the Department of Oral Sciences and Maxillofacial Surgery at "Sapienza" University of Rome, and were included in the study. The 12-item Short Form Survey was used to evaluate the QoL. Statistical analysis revealed a significant difference for Mental Component Summary (MCS) scores based on age (p = 0.018). The regression analysis revealed that the Physical Component Summary (PCS) scores were negatively influenced by the anti-resorptive medication duration (p = 0.031 and β = -1.137). No significant differences were observed with the other variables considered. The QoL of cancer patients is generally deteriorated and MRONJ may cause a further negative impact. This study highlights the possible need to include psychosocial and physical evaluations in the management process of MRONJ in cancer patients.
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Authors | Gianluca Tenore, Ahmed Mohsen, Antonella Francesca Rossi, Gaspare Palaia, Federica Rocchetti, Andrea Cassoni, Valentino Valentini, Livia Ottolenghi, Antonella Polimeni, Umberto Romeo |
Journal | Biomedicines
(Biomedicines)
Vol. 8
Issue 4
(Apr 24 2020)
ISSN: 2227-9059 [Print] Switzerland |
PMID | 32344782
(Publication Type: Journal Article)
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