Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: We carried out a prospective clinical trial (a randomized and open-label study) in patients with type 2 diabetes mellitus and NAFLD. A total of 98 patients were randomly allocated either to the dapagliflozin (n = 32), pioglitazone (n = 33) or glimepiride (n = 33) group, and the patients took these drugs for 28 weeks. The primary end-point was the change of the liver-to-spleen ratio on abdominal computed tomography. RESULTS: CONCLUSIONS:
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Authors | Tomoe Kinoshita, Masashi Shimoda, Koji Nakashima, Yoshiro Fushimi, Yurie Hirata, Akihito Tanabe, Fuminori Tatsumi, Hidenori Hirukawa, Junpei Sanada, Kenji Kohara, Shintaro Irie, Tomohiko Kimura, Yoshiko Nakamura, Momoyo Nishioka, Atsushi Obata, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 11
Issue 6
Pg. 1612-1622
(Nov 2020)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 32329963
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Benzhydryl Compounds
- Biomarkers
- Blood Glucose
- Glucosides
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Sodium-Glucose Transporter 2 Inhibitors
- Sulfonylurea Compounds
- hemoglobin A1c protein, human
- dapagliflozin
- glimepiride
- Pioglitazone
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Topics |
- Benzhydryl Compounds
(therapeutic use)
- Biomarkers
(analysis)
- Blood Glucose
(analysis)
- Case-Control Studies
- Diabetes Mellitus, Type 2
(complications, drug therapy, pathology)
- Female
- Follow-Up Studies
- Glucosides
(therapeutic use)
- Glycated Hemoglobin
(analysis)
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Intra-Abdominal Fat
(drug effects, pathology)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(drug therapy, etiology, pathology)
- Pioglitazone
(therapeutic use)
- Prognosis
- Prospective Studies
- Sodium-Glucose Transporter 2 Inhibitors
(therapeutic use)
- Sulfonylurea Compounds
(therapeutic use)
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