A tumor microenvironment (TME) responsive cascade nanocatalyst was built based on
copper-embedded hollow mesoporous
silica (
HMSN-Cu) decorated with
glucose oxidase (GOD) on the surface, realizing
tumor-selected cascade catalyst for elegant combination of starving
therapy and chemodynamic
therapy. Specifically, benefited from the strong demand for
glucose metabolism in
tumor cells, this
HMSN-Cu-GOD could catalyze rich
glucose into H2O2 in the presence of O2, along with localized declined pH in situ to in turn degrade
HMSN-Cu and thus release Cu2+/Cu+. Importantly, abound
hydroxyl radical (•OH) with high oxidative activity generated in the Fenton reaction between H2O2 and Cu2+/Cu+. Interesting, the high-expressed GSH and exacerbated
hypoxia in
tumor cells, will facilitate accumulation of Cu+ with much higher reaction efficiency, further enhanced Chemodynamic
therapy (CDT) efficiency. Compared with monotherapy, in vitro and vivo
tumor inhibition experiments demonstrated the superior synergistic effect of CDT and starving
therapy based on a simple but effective biodegradable nanosystem.