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[PRIMARY PROSTATIC RHABDOMYOSARCOMA WITH REPEATING CEREBRAL HEMORRHAGE FROM BRAIN METASTASES IN AN ADULT: A CASE REPORT].

Abstract
A 28-year-old man visited a nearby doctor with a chief complaint of hematospermia. Magnetic resonance imaging showed a tumor 12-cm in diameter in his pelvis and he was introduced to our hospital. The tumor had replaced the prostate and infiltrated the rectum. He already had multiple lung, pelvic lymph, and bone metastases. He was diagnosed with embryonal rhabdomyosarcoma based on pathological findings after needle tumor biopsy. His disease was stage IV rhabdomyosarcoma according to the Intergroup Rhabdomyosarcoma Study, and he received a VAC (vincristine, actinomycin D, cyclophosphamide) chemotherapy regimen. Despite a partial response with 44% shrinkage in tumor diameter after seven cycles of chemotherapy, he experienced cerebral hemorrhage from small brain metastases during preparation for the eighth course. During gamma knife planning, the cerebral hemorrhage from small brain metastases repeated four times. The patient died 8 months after the introduction of chemotherapy.
AuthorsKosuke Tochigi, Naoto Sassa, Yoshie Kanada, Tomoyoshi Ohashi, Satoshi Inoue, Shun Takai, Kazuna Matsuo, Tsuyoshi Majima, Shohei Ishida, Yasuhito Funahashi, Takashi Fujita, Yoshihisa Matsukawa, Masashi Kato, Tokunori Yamamoto, Momokazu Gotoh
JournalNihon Hinyokika Gakkai zasshi. The japanese journal of urology (Nihon Hinyokika Gakkai Zasshi) Vol. 110 Issue 2 Pg. 119-123 ( 2019) ISSN: 1884-7110 [Electronic] Japan
PMID32307379 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Dactinomycin
  • Vincristine
  • Cyclophosphamide
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Brain Neoplasms (secondary)
  • Cerebral Hemorrhage
  • Cyclophosphamide
  • Dactinomycin (administration & dosage)
  • Fatal Outcome
  • Humans
  • Male
  • Prostatic Neoplasms (drug therapy, pathology)
  • Recurrence
  • Rhabdomyosarcoma (drug therapy, pathology)
  • Vincristine (administration & dosage)

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