Prolonged Postoperative Intubation After Spinal Fusion in Cerebral Palsy: Are There Modifiable Risk Factors and Associated Consequences?

Abstract

BACKGROUND:

Instrumented spinal fusion is performed to correct severe spinal deformity that commonly complicates cerebral palsy (CP). Prolonged intubation (PI) is a common perioperative complication, though little is known about the risk factors and consequences of this phenomenon.

QUESTIONS/PURPOSES:

The purpose of this study was to determine (1) the preoperative and intraoperative risk factors associated with PI after spine surgery for CP; (2) the perioperative and postoperative complications associated with PI; and (3) any long-term impacts of PI with respect to health-related quality of life.

PATIENTS AND METHODS:

A retrospective case-control analysis of prospectively collected, multicenter data was performed on patients with Gross Motor Function Classification System (GMFCS) 4 or 5 CP who underwent instrumented spinal fusion. Patients extubated on postoperative day (POD) 0 were in the early extubation (EE) cohort and those extubated on POD 3 or later were in the PI cohort. Comparisons were made between PI and EE groups with respect to several preoperative and intraoperative variables to identify risk factors for PI. Multivariate logistic regression was performed to identify independent predictors of this outcome. The postoperative hospital course, rate of complications, and health-related quality of life at 2 years were also compared.

RESULTS:

This study included 217 patients (52% male individuals; mean age, 14.0±2.8 y) who underwent spinal fusion for CP. In this cohort, 52 patients (24%) had EE and 58 patients (27%) had PI. There were several independent predictors of PI including history of pneumonia [odds ratio (OR), 6.2; 95% confidence interval (CI), 1.6-24.3; P=0.01], estimated blood loss of >3000 mL (OR, 16.5; 95% CI, 2.0-134; P=0.01), weight of <37 kg (OR, 6.4; 95% CI, 1.5-27.1), and Child Health Index of Life with Disabilities (CPCHILD) Communication and Social Interaction score of <15 (OR, 10.8; 95% CI, 1.1-107.3; P=0.04). In addition, PI was associated with a higher rate of perioperative and postoperative respiratory (P<0.001), cardiovascular (P=0.014), gastrointestinal (P<0.001), and surgical site (0.027) complications, in addition to prolonged hospitalization (P<0.001) and intensive care unit stay (P<0.001).

CONCLUSIONS:

Surgeons should seek to optimize nutritional status and pulmonary function, and minimize blood loss in patients with CP to decrease the risk of PI after spinal fusion. Efforts should be made to extubate patients on POD 0 to decrease the risk of complications associated with PI.

• Authors: Scott M LaValva, Keith Baldwin, Ishaan Swarup, John M Flynn, Joshua M Pahys, Burt Yaszay, Mark F Abel, Keith Bachmann, Suken A Shah, Paul D Sponseller, Patrick J Cahill, Harms Study Group
• Journal: Journal of pediatric orthopedics (J Pediatr Orthop) Vol. 40 Issue 8 Pg. 431-437 (Sep 2020) ISSN: 1539-2570 [Electronic] United States
• PMID: 32301849 (Publication Type: Journal Article)

Topics

• Adolescent
• Case-Control Studies
• Cerebral Palsy (surgery)
• Duration of Therapy
• Female
• Humans
• Intubation, Intratracheal (adverse effects, statistics & numerical data)
• Male
• Needs Assessment
• Postoperative Care (methods, statistics & numerical data)
• Postoperative Complications (therapy)
• Retrospective Studies
• Risk Adjustment (methods)
• Risk Factors
• Spinal Fusion (adverse effects, methods)