Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2.

Abstract

INTRODUCTION:

The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function.

METHODS:

Observational analyses of participants (n = 7,756) enrolled in two randomized trials of nutritional supplements for age-related macular degeneration: Age-Related Eye Disease Study (AREDS) and AREDS2.

RESULTS:

Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini-Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status-Modified (<30) and 0.48 for composite score (each P < .0001) in AREDS2. Fish intake was associated with higher cognitive function. In AREDS2, rate of cognitive decline over 5 to 10 years was not significantly different by aMED but was significantly slower (P = .019) with higher fish intake.

DISCUSSION:

Closer Mediterranean diet adherence was associated with lower risk of cognitive impairment but not slower decline in cognitive function. Apolipoprotein E (APOE) haplotype did not influence these relationships.

• Authors: Tiarnán D Keenan, Elvira Agrón, Julie A Mares, Traci E Clemons, Freekje van Asten, Anand Swaroop, Emily Y Chew, AREDS and AREDS2 Research Groups
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 16 Issue 6 Pg. 831-842 (06 2020) ISSN: 1552-5279 [Electronic] United States
• PMID: 32285590 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Alzheimer's Association. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

Chemical References

• Apolipoproteins E

Topics

• Aged
• Aged, 80 and over
• Apolipoproteins E (genetics)
• Cognition (physiology)
• Cognitive Dysfunction (diagnosis, genetics)
• Diet, Mediterranean
• Disease Progression
• Female
• Haplotypes
• Humans
• Macular Degeneration
• Male
• Middle Aged
• Neuropsychological Tests