Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent.

Abstract

The essential oil obtained by the fresh fruit of Citrus bergamia Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize the effects of stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot essential oil (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable to that of the benzodiazepine diazepam, suggesting that neurotransmissions, other than GABAergic, could be involved. Several studies on essential oils indicate a role for serotonergic (5-HT) neurotransmission in anxiety. Interestingly, among serotonergic receptors, the 5-HT1A subtype seems to play a key role in the control of anxiety. Here, we report that modulation of the 5-HT1A receptor by selective agonist ((±)8-OH-DPAT) or antagonist (WAY-100635) may influence some of the anxiolytic-relaxant effects of BEO in Open Field and Elevated Plus Maze tests.

• Authors: Laura Rombolà, Damiana Scuteri, Chizuko Watanabe, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 21 Issue 7 (Apr 09 2020) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 32283606 (Publication Type: Journal Article)

Chemical References

• Anti-Anxiety Agents
• Oils, Volatile
• Piperazines
• Plant Oils
• Pyridines
• Serotonin Antagonists
• Serotonin Receptor Agonists
• Receptor, Serotonin, 5-HT1A
• bergamot oil
• N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
• 8-Hydroxy-2-(di-n-propylamino)tetralin

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
• Animals
• Anti-Anxiety Agents (chemistry, pharmacology)
• Anxiety (drug therapy, etiology, metabolism)
• Behavior, Animal (drug effects)
• Disease Models, Animal
• Male
• Maze Learning
• Motor Activity
• Oils, Volatile (chemistry, pharmacology)
• Piperazines (pharmacology)
• Plant Oils (chemistry, pharmacology)
• Pyridines (pharmacology)
• Rats
• Receptor, Serotonin, 5-HT1A (metabolism)
• Rodentia
• Serotonin Antagonists (pharmacology)
• Serotonin Receptor Agonists (pharmacology)
• Synaptic Transmission (drug effects)