Piperlongumine, a white to beige biologically active
alkaloid/
amide phytochemical, has high pharmacological relevance as an
anticancer agent.
Piperlongumine has several
biological activities, including selective cytotoxicity against multiple
cancer cells of different origins at a preclinical level. Several preclinical studies have documented the anticancer potential of
piperlongumine through its targeting of multiple molecular mechanisms, such as cell cycle arrest, anti-angiogenesis, anti- invasive and anti-
metastasis pathways, autophagy pathways, and intrinsic apoptotic pathways in vitro and in vivo. Mechanistically,
piperlongumine inhibits
cancer growth by resulting in the accumulation of intracellular
reactive oxygen species, decreasing
glutathione and chromosomal damage, or modulating key regulatory
proteins, including PI3K, AKT, mTOR, NF-kβ, STATs, and
cyclin D1. Furthermore, combined treatment with
piperlongumine potentiates the anticancer activity of conventional chemotherapeutics and overcomes resistance to chemo- and radio-
therapy. Nanoformulation of
piperlongumine has been associated with increased aqueous solubility and bioavailability and lower toxicity, thus enhancing therapeutic efficacy in both preclinical and clinical settings. The current review highlights anticancer studies on the occurrence, chemical properties, chemopreventive mechanisms, toxicity, bioavailability, and
pharmaceutical relevance of
piperlongumine in vitro and in vivo.