Abstract | INTRODUCTION:
Statins have been associated with improved clinical outcomes in patients with viral hepatitis and after variceal bleeding. Still, the clinical benefit of statins is not well defined for different liver diseases. Moreover, associations between statin use and liver stiffness as well as event free survival have not been established. METHODS: Liver stiffness was evaluated in 6490 patients with liver disease (January 2012 till December 2016). Two hundred thirty-four of those received statin therapy, 468 controls without statins were selected by a 1:2 case by case matching using age, sex, underlying liver disease and BMI. RESULTS: CONCLUSIONS: Use of statins was well tolerated irrespective of liver disease. Statin users showed reduced hepatic inflammatory activity, less severe markers of liver stiffness and portal hypertension. There might be a beneficial effect of statin on the risk to experience hepatic decompensation.
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Authors | Antoaneta A Markova, Katja Deterding, Kerstin Port, Heike Bantel, Michael P Manns, Markus Cornberg, Heiner Wedemeyer |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 32
Issue 2
Pg. 223-229
(02 01 2021)
ISSN: 1473-5687 [Electronic] England |
PMID | 32282399
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
|
Topics |
- Esophageal and Gastric Varices
- Gastrointestinal Hemorrhage
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(adverse effects)
- Liver Neoplasms
|