CTLA4 +49AG (rs231775) and CT60 (rs3087243) gene variants are not associated with alopecia areata in a Mexican population from Monterrey Mexico.

Abstract

BACKGROUND:

Alopecia areata is an autoimmune disease that produces non-scarring hair loss around the body. Gene variants of the cytotoxic T-lymphocyte antigen 4 (CTLA4) gene, a negative regulator of T-cell response, have been associated with a predisposition to autoimmune diseases in different populations; however, the involvement of these genetic variants in the development of AA is controversial.

OBJECTIVE:

The present study evaluated the potential association of two CTLA4 gene variants with alopecia areata in a Mexican population.

METHODS:

We genotyped +49AG (rs231775) and CT60 (rs3087243) variants in 50 AA patients and 100 healthy control participants through PCR-RFLP.

RESULTS:

No statistical difference was observed for either of the gene variants regarding allele or genotype frequencies between AA patients and the controls when the parameters of family/personal history of autoimmune diseases or gender were considered (p>0.05).

STUDY LIMITATIONS:

Small sample size of patients and the data were obtained from Northeast Mexico population.

CONCLUSION:

The genetic variants rs231775 and rs3087243 of the CTLA4 gene are not a risk factor for the development of alopecia areata in the analyzed Mexican population.

• Authors: Mauricio Andrés Salinas-Santander, Cristina Susana Cantu-Salinas, Jorge Ocampo-Candiani, Victor de Jesus Suarez-Valencia, Jennifer Guadalupe Ramirez-Guerrero, Celia Nohemi Sanchez-Dominguez
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2020 May - Jun Vol. 95 Issue 3 Pg. 283-288 ISSN: 1806-4841 [Electronic] Spain
• PMID: 32278632 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier España, S.L.U. All rights reserved.

Chemical References

• CTLA-4 Antigen
• CTLA4 protein, human

Topics

• Adolescent
• Adult
• Alopecia Areata (genetics)
• CTLA-4 Antigen (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genetic Variation (genetics)
• Genotyping Techniques
• Humans
• Male
• Mexico
• Middle Aged
• Polymorphism, Single Nucleotide
• Risk Factors
• Young Adult