Abstract | BACKGROUND: METHODS: RESULTS:
Rapamycin-treated cells exhibited dysfunction of mitochondrial respiration and decreased mitochondrial gene expression compared with rapamycin- metformin-treated cells. Moreover, rapamycin- metformin reduced the clinical arthritis score and the extent of histological inflammation and improved the metabolic profile in obese mice with CIA. Rapamycin- metformin enhanced the balance between T helper 17 and regulatory T cells in vitro and in vivo. CONCLUSIONS:
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Authors | Eun Kyung Kim, Hong Ki Min, Seon-Yeong Lee, Da-Som Kim, Jun-Geol Ryu, Hyun Sik Na, Kyoung Ah Jung, Jeong Won Choi, Sung-Hwan Park, Mi-La Cho |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 22
Issue 1
Pg. 77
(04 10 2020)
ISSN: 1478-6362 [Electronic] England |
PMID | 32276645
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypoglycemic Agents
- Immunosuppressive Agents
- Metformin
- Sirolimus
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Topics |
- Animals
- Arthritis, Experimental
(complications, metabolism, pathology)
- Arthritis, Rheumatoid
(complications, metabolism, pathology)
- Drug Therapy, Combination
(methods)
- Hypoglycemic Agents
(administration & dosage)
- Immunosuppressive Agents
(administration & dosage)
- Metabolic Syndrome
(complications)
- Metformin
(administration & dosage)
- Mice
- Mitochondria
(drug effects)
- Obesity
(complications, metabolism)
- Sirolimus
(administration & dosage)
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