Synthesis and drug delivery of novel amphiphilic block copolymers containing hydrophobic dehydroabietic moiety.

Abstract

Well-defined amphiphilic poly(ethylene glycol) and poly(dehydroabietic ethyl methacrylate) block copolymers (PEG-b-PDAEMA) were prepared by atom transfer radical polymerization. The methacrylate block contains a characteristic hydrophobic, biocompatible and economical dehydroabietic moiety. PEG-b-PDAEMA block copolymer micellar nanoparticles loaded with piperlongumine (PLGM) were successfully prepared by a nanoprecipitation method. In vitro and in vivo behaviors of these nanoparticles were thoroughly examined by a set of characterization techniques. Confocal laser scanning microscopy study revealed that these nanoparticles could be well taken up by cancer cells. In vivo near-infrared fluorescence imaging showed that the PLGM-loaded nanoparticles effectively targeted the tumor site by the enhanced permeability and retention (EPR) effect in H22 tumor-bearing mice. The in vivo antitumor examination found that PLGM-loaded nanoparticles exhibited superior efficacy in impeding the tumor growth compared to the commercially available Taxol® and free PLGM formulation. The changes in body weights and blood biochemical profiles were also compared to investigate the safety of PLGM and PEG-b-PDAEMA nanoparticle drug delivery system.

• Authors: Jing Wang , Kejian Yao , Chongzhi Wang , Chuanbing Tang , Xiqun Jiang
• Journal: Journal of materials chemistry. B (J Mater Chem B) Vol. 1 Issue 17 Pg. 2324-2332 (May 07 2013) ISSN: 2050-7518 [Electronic] England
• PMID: 32260886 (Publication Type: Journal Article)