Recent advances in electrospun nanofiber-mediated drug delivery strategies for localized cancer chemotherapy.

Abstract

Nanotechnology empowered localized cancer chemotherapy has indicated a promising performance for targeting and controlled release of anticancer agents over a period of time to eliminate local-regional recurrence of cancers and also to improve the tissue regeneration during/after treatment. Electrospun nanofiber-based implantable drug-delivery systems have been established as one of the most effective approaches for localized cancer treatment, allowing the on-site delivery of anticancer agents and reducing systemic toxicities and side effects to normal cells. The present review aimed to summarize the latest cutting-edge research on applications of electrospun-based systems for local chemotherapy. Meantime, in vitro and in vivo studies conducted using various anticancer agents along with the capability of electrospun nanofibers for combinatorial/synergistic chemotherapy as well as existing challenges and the potential dramatic advances in applying this pioneering approach for clinical transition in localized treatments of cancer is also discussed.

• Authors: Meysam Khodadadi, Sepideh Alijani, Maryam Montazeri, Niloufar Esmaeilizadeh, Shima Sadeghi-Soureh, Younes Pilehvar-Soltanahmadi
• Journal: Journal of biomedical materials research. Part A (J Biomed Mater Res A) Vol. 108 Issue 7 Pg. 1444-1458 (05 2020) ISSN: 1552-4965 [Electronic] United States
• PMID: 32246745 (Publication Type: Journal Article, Review)
• Copyright: © 2020 Wiley Periodicals, Inc.

Chemical References

• Antineoplastic Agents
• Delayed-Action Preparations

Topics

• Animals
• Antineoplastic Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Delayed-Action Preparations (chemistry)
• Drug Delivery Systems (methods)
• Humans
• Nanofibers (chemistry)
• Nanotechnology (methods)
• Neoplasms (drug therapy)