Abstract |
The use of adjuvant radiotherapy is controversial in patients with atypical meningiomas treated with gross total resection (GTR). This study aimed to determine whether clinico-pathological features could be helpful to predict the recurrence risk in this group of patients and to identify high-risk ones who could benefit from adjuvant treatment. We collected 200 patients with primary atypical meningiomas treated with GTR but with no adjuvant radiotherapy from 5 different centers. A risk score, formulated by assigning 1 point for the presence and 0 points for the absence of 5 high-risk parameters (male sex, parasagittal site, Simpson grade 3, mitotic index ≥ 6/10 HPF, and sheeting), was the most significant predictor of recurrence. A score ≥2 was associated with 4.7 risk of shorter disease-free survival (p < 0.0001). Our findings indicate that the presence of at least 2 clinico-pathological high-risk factors predicts recurrence of totally resected primary atypical meningiomas and could be helpful for identifying patients who could benefit from adjuvant radiotherapy.
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Authors | Adele Fioravanzo, Maria Caffo, Rina Di Bonaventura, Marina Paola Gardiman, Claudio Ghimenton, Tamara Ius, Valeria Maffeis, Maurizio Martini, Antonio Nicolato, Roberto Pallini, Enrico Pegolo, Giampietro Pinna, Francesco Sala, Miran Skrap, Valerio Volpin, Valeria Barresi |
Journal | Journal of neuropathology and experimental neurology
(J Neuropathol Exp Neurol)
Vol. 79
Issue 5
Pg. 500-507
(05 01 2020)
ISSN: 1554-6578 [Electronic] England |
PMID | 32232472
(Publication Type: Journal Article)
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Copyright | © 2020 American Association of Neuropathologists, Inc. All rights reserved. |
Topics |
- Humans
- Male
- Meningeal Neoplasms
(diagnosis, pathology, surgery)
- Meningioma
(diagnosis, pathology, surgery)
- Neoplasm Recurrence, Local
- Prognosis
- Radiotherapy, Adjuvant
- Retrospective Studies
- Risk Factors
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