Abstract | OBJECTIVE: METHODS: Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein AI, apolipoprotein B, and lipid ratios were measured at the time of amyotrophic lateral sclerosis diagnosis or shortly thereafter. Death after amyotrophic lateral sclerosis diagnosis was used as the main outcome. The Cox model was used to estimate hazard ratios with 95% confidence intervals of death after amyotrophic lateral sclerosis diagnosis, after controlling for sex, age at diagnosis, site of symptom onset, diagnostic delay, body mass index, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised score, and progression rate. RESULTS: A 1-SD increase of total cholesterol (hazard ratio 0.60, 95% confidence interval 0.41-0.89, p = 0.01), low-density lipoprotein cholesterol (hazard ratio 0.64, 95% confidence interval 0.44-0.92, p = 0.02), low-density lipoprotein cholesterol/ high-density lipoprotein cholesterol ratio (hazard ratio 0.65, 95% confidence interval 0.46-0.92, p = 0.02), apolipoprotein B (hazard ratio 0.62, 95% confidence interval 0.44-0.88, p = 0.01), or apolipoprotein B/ apolipoprotein AI ratio (hazard ratio 0.61, 95% confidence interval 0.43-0.86, p < 0.01) was associated with a lower risk of death after amyotrophic lateral sclerosis diagnosis. A dose-response relationship was also noted when these biomarkers were analyzed as categorical variables. CONCLUSIONS:
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Authors | Caroline Ingre, Lin Chen, Yiqiang Zhan, Jet Termorshuizen, Li Yin, Fang Fang |
Journal | Neurology
(Neurology)
Vol. 94
Issue 17
Pg. e1835-e1844
(04 28 2020)
ISSN: 1526-632X [Electronic] United States |
PMID | 32221024
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. |
Chemical References |
- Apolipoproteins
- Biomarkers
- Lipids
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Topics |
- Aged
- Amyotrophic Lateral Sclerosis
(blood, mortality)
- Apolipoproteins
(blood)
- Biomarkers
(blood)
- Cohort Studies
- Female
- Humans
- Lipids
(blood)
- Male
- Middle Aged
- Prognosis
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