Effect of HtrA1 Polymorphism on Sensitivity to Chemotherapy in Patients with Colon Cancer.

Abstract

BACKGROUND This study was performed to estimate the genetic effects of HtrA1 polymorphisms rs1049331 and rs11200638 on treatment response in stage III colon cancer patients receiving 5-FU-based chemotherapy. MATERIAL AND METHODS A total of 105 stage III colon cancer patients who received postoperative 5-FU based adjuvant chemotherapy were included in our study. Chemotherapy was performed in 3 cycles for the patients. HtrA1 rs1049331 and rs11200638 polymorphisms were genotyped via polymerase chain reaction with sequencing method. The treatment response was estimated according to the RECIST guidelines. RESULTS The response rate of the eligible patients was 53.33%. For rs1049331, the presences of TT genotype and T allele indicted reduced chemotherapy sensitivity (adjusted TT: OR=1.736, 95%CI: 1.001-3.011, P=0.049; T: OR=1.801, 95%CI: 1.054-2.932, P=0.039). The rs11200638 polymorphism had no significant association with chemotherapy sensitivity in the study population (P>0.05 for all). CONCLUSIONS HtrA1 rs1049331 polymorphism, but not rs11200638 polymorphism, can influence individual sensitivity to 5-FU-based treatment in stage III colon cancer patients.

• Authors: Yi Yao, Nan Li
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 26 Pg. e921933 (Mar 27 2020) ISSN: 1643-3750 [Electronic] United States
• PMID: 32218415 (Publication Type: Journal Article, Observational Study)

Chemical References

• Antimetabolites, Antineoplastic
• High-Temperature Requirement A Serine Peptidase 1
• HTRA1 protein, human
• Fluorouracil

Topics

• Adult
• Antimetabolites, Antineoplastic (pharmacology, therapeutic use)
• Asian People
• Case-Control Studies
• Chemotherapy, Adjuvant
• Colectomy
• Colon (pathology, surgery)
• Colonic Neoplasms (genetics, pathology, therapy)
• Drug Resistance, Neoplasm (genetics)
• Female
• Fluorouracil (pharmacology, therapeutic use)
• High-Temperature Requirement A Serine Peptidase 1 (genetics)
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Polymorphism, Single Nucleotide
• Response Evaluation Criteria in Solid Tumors