HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery.

Abstract
A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.
AuthorsDeyao Zhao, Ge Yang, Qing Liu, Wenjing Liu, Yuhua Weng, Yi Zhao, Feng Qu, Lele Li, Yuanyu Huang
JournalNanoscale (Nanoscale) Vol. 12 Issue 20 Pg. 10939-10943 (May 28 2020) ISSN: 2040-3372 [Electronic] England
PMID32207496 (Publication Type: Journal Article)
Chemical References
  • AGRO 100
  • Aptamers, Nucleotide
  • Drug Carriers
  • Oligodeoxyribonucleotides
  • RNA, Small Interfering
Topics
  • Animals
  • Aptamers, Nucleotide (pharmacokinetics, pharmacology)
  • Cell Line, Tumor
  • Drug Carriers (pharmacokinetics, pharmacology)
  • Gene Expression Regulation, Neoplastic
  • Gene Silencing
  • Mice
  • Neoplasms (drug therapy, genetics, metabolism, pathology)
  • Oligodeoxyribonucleotides (pharmacokinetics, pharmacology)
  • RNA, Small Interfering (pharmacokinetics, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: