Abstract |
A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.
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Authors | Deyao Zhao, Ge Yang, Qing Liu, Wenjing Liu, Yuhua Weng, Yi Zhao, Feng Qu, Lele Li, Yuanyu Huang |
Journal | Nanoscale
(Nanoscale)
Vol. 12
Issue 20
Pg. 10939-10943
(May 28 2020)
ISSN: 2040-3372 [Electronic] England |
PMID | 32207496
(Publication Type: Journal Article)
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Chemical References |
- AGRO 100
- Aptamers, Nucleotide
- Drug Carriers
- Oligodeoxyribonucleotides
- RNA, Small Interfering
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Topics |
- Animals
- Aptamers, Nucleotide
(pharmacokinetics, pharmacology)
- Cell Line, Tumor
- Drug Carriers
(pharmacokinetics, pharmacology)
- Gene Expression Regulation, Neoplastic
- Gene Silencing
- Mice
- Neoplasms
(drug therapy, genetics, metabolism, pathology)
- Oligodeoxyribonucleotides
(pharmacokinetics, pharmacology)
- RNA, Small Interfering
(pharmacokinetics, pharmacology)
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