Abstract | INTRODUCTION: METHODS: Spinal cord at level of T6-T8 was compressed. Three weeks after spinal cord injury, muscimol and endomorphin-1 were injected (intrathecally once a day for 7 days) individually or in combination. Mechanical and cold allodynia, thermal and mechanical hyperalgesia were evaluated before injection and 15 and 60 min after injection. At the end of behavioral experiments, histological and biochemical evaluations were done on prepared spinal cord samples. RESULTS: CONCLUSION:
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Authors | Marjan Hosseini, Zohreh Karami, Mahmood Yousefifard, Atousa Janzadeh, Elham Zamani, Farinaz Nasirinezhad |
Journal | Brain and behavior
(Brain Behav)
Vol. 10
Issue 5
Pg. e01576
(05 2020)
ISSN: 2162-3279 [Electronic] United States |
PMID | 32189472
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. |
Chemical References |
- Oligopeptides
- endomorphin 1
- Muscimol
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Topics |
- Animals
- Hyperalgesia
(drug therapy)
- Injections, Spinal
- Muscimol
(pharmacology, therapeutic use)
- Neuralgia
(drug therapy)
- Oligopeptides
- Rats
- Spinal Cord
- Spinal Cord Injuries
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