The Efficacy of Lung Volume Reduction Coil Treatment in Patients with Severe Chronic Obstructive Pulmonary Disease (COPD) Type II Respiratory Failure.

Abstract

Purpose:

Emphysema is a progressive and irreversible disease, proceeding with the decrease in elastic recoil which is connected to tissue damage caused by chronic inflammation. Lung volume reduction coil (LVRC) method in patients with an advanced level of emphysema and irresponsive to medical treatment is shown to provide increase in lung volumes and exercise capacity, decrease in dyspnea, and increase in quality of life. The purpose of this study is to reveal that LVRC treatment is also efficient in severe COPD patients with hypercapnic respiratory failure.

Patients and Methods:

Eleven cases with severe COPD and emphysema were included in the study. LVRC treatment method was applied in upper lobes of both lungs in patients with severe COPD (FEV1 < %45) and Type-2 respiratory insufficiency (PCO2 55-80 mmHg) who were having medical treatment and CPAP treatment. The patients were followed up for a period of twelve months using arterial blood gas analysis.

Results:

Beginning with the first month of the LVRC treatment, PCO2 levels were found to be significantly decreased in all patients using arterial blood gas analysis.

Conclusion:

LVRC method can provide physiological and functional recovery and progress in quality of life in severe COPD cases. It is demonstrated that LVRC treatment caused significant decreases in carbon dioxide levels as well as causing improvement in life quality and respiratory function tests in the patients with hypercapnic respiratory failure.

• Authors: Fidan Yildiz
• Journal: International journal of chronic obstructive pulmonary disease (Int J Chron Obstruct Pulmon Dis) Vol. 15 Pg. 479-486 ( 2020) ISSN: 1178-2005 [Electronic] New Zealand
• PMID: 32184585 (Publication Type: Journal Article)
• Copyright: © 2020 Yildiz.

Chemical References

• Biomarkers
• Carbon Dioxide

Topics

• Aged
• Biomarkers (blood)
• Bronchoscopy (adverse effects, instrumentation)
• Carbon Dioxide (blood)
• Female
• Forced Expiratory Volume
• Humans
• Lung (physiopathology)
• Male
• Middle Aged
• Pulmonary Disease, Chronic Obstructive (blood, diagnosis, physiopathology, therapy)
• Pulmonary Emphysema (blood, diagnosis, physiopathology, therapy)
• Quality of Life
• Recovery of Function
• Respiratory Insufficiency (blood, diagnosis, physiopathology, therapy)
• Retrospective Studies
• Severity of Illness Index
• Time Factors
• Total Lung Capacity
• Treatment Outcome