Thrombocytopenia-Associated Multiple Organ Failure.

Abstract

Thrombocytopenia-associated multiple organ failure is a clinical phenotype encompassing a spectrum of syndromes associated with disseminated microvascular thromboses. Autopsies performed in patients that died with thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, or disseminated intravascular coagulation reveal specific findings that can differentiate these 3 entities. Significant advancements have been made in our understanding of the pathologic mechanisms of these syndromes. Von Willebrand factor and ADAMTS-13 play a central role in thrombotic thrombocytopenic purpura. Shiga toxins and the complement pathway drive the hemolytic uremic syndrome pathology. Tissue factor activity is vital in the development of disseminated intravascular coagulation.

• Authors: Trung C Nguyen
• Journal: Critical care clinics (Crit Care Clin) Vol. 36 Issue 2 Pg. 379-390 (Apr 2020) ISSN: 1557-8232 [Electronic] United States
• PMID: 32172819 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Topics

• Disseminated Intravascular Coagulation (complications, genetics, therapy)
• Genetic Predisposition to Disease
• Hemolytic-Uremic Syndrome (complications, genetics, therapy)
• Humans
• Multiple Organ Failure (etiology, genetics, therapy)
• Phenotype
• Plasma Exchange
• Thrombocytopenia (complications, genetics, therapy)