Abstract | OBJECTIVE: METHODS: Studies related to aspirin therapy for Kawasaki disease were selected by searching the databases of Medline (PubMed), Embase and the Cochrane Library before March 2019. Statistical analyses were performed by using a Review Manager Software package and STATA v.15.1. RESULTS: Eight retrospective cohort studies, characterizing 12 176 patients, were analysed. Overall, no significant difference was found in the incidence of coronary artery abnormalities between the high- and low-dose aspirin groups [relative risk (RR) 1.15; 95% CI: 0.93, 1.43; P = 0.19; random-effects model]. The patients treated with high-dose aspirin had slightly faster resolution of fever [mean difference (MD) -0.30; 95% CI: -0.58, -0.02; P = 0.04; random-effects model]. but the rates of IVIG resistance (RR, 1.26; 95% CI: 0.55, 2.92; P = 0.59; random-effects model) and days in hospital (MD, 0.22; 95% CI: -0.93, 1.37; P = 0.71; random-effects model) were similar between the two groups. CONCLUSION:
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Authors | Xinyi Jia, Xiao Du, Shuxian Bie, Xiaobing Li, Yunguang Bao, Mizu Jiang |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 59
Issue 8
Pg. 1826-1833
(08 01 2020)
ISSN: 1462-0332 [Electronic] England |
PMID | 32159800
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected]. |
Chemical References |
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Topics |
- Aspirin
(administration & dosage, therapeutic use)
- Dose-Response Relationship, Drug
- Humans
- Mucocutaneous Lymph Node Syndrome
(drug therapy)
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