[A Case of Pathological CR in Local Advanced Rectal Cancer Treated with Laparoscopic ISR after XELOXIRI Chemotherapy].

Abstract

A 67-year-old man without a history of surgery presented with bloody stool and anal pain. Colonoscopy and abdominal CT revealed locally advanced rectal cancer with right lateral lymph node metastasis. We administered 6courses of neoadjuvant therapy with capecitabine, oxaliplatin, and irinotecan(XELOXIRI)to the patient. After neoadjuvant chemotherapy, remarkable tumor shrinkage was observed. The patient underwent safety intrasphincteric resection(ISR)and lateral lymph node dissection with anal preservation. The postoperative course was uneventful, and he was discharged 17 days postoperatively. Pathologically, no residual cancer cells were observed in the rectum and lymph nodes(pathological CR). This case of locally advanced rectal cancer was successfully treated with laparoscopic ISR after XELOXIRI chemotherapy, and showed pathological CR. ISR after neoadjuvant XELOXIRI chemotherapy was safely performed and might be a good option for locally advanced rectal cancer.

• Authors: Kenji Kawai, Kohei Murata, Taishi Hata, Yoshinori Kagawa, Atsushi Naito, Takuya Sakamoto, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Omura, Toru Masuzawa, Atsushi Takeno, Yutaka Takeda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 46 Issue 13 Pg. 2096-2097 (Dec 2019) ISSN: 0385-0684 [Print] Japan
• PMID: 32157071 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Humans
• Laparoscopy
• Male
• Neoadjuvant Therapy
• Rectal Neoplasms (drug therapy, surgery)
• Rectum