[A Case of Small Cell Carcinoma of the Pancreas].

Abstract

A 55-year-old man was admitted to our hospital for jaundice. Magnetic resonance cholangiopancreatography showed a mass in the pancreatic head as well as biliary obstruction. We strongly suspected invasive ductal carcinoma of the pancreas. We performed pancreaticoduodenectomy with partial resection of the portal vein. The histopathological diagnosis was small cell carcinoma of the pancreas. We detected metastasis of the right hilar lymph node in PET-CT scan performed 2 months after the surgery and started chemotherapy with cisplatin(CDDP)plus irinotecan(CPT-11). However, we observed recurrent metastasis of the right hilar lymph node 12 months after the surgery. We started second-line chemotherapy with amrubicin( AMR)and radiotherapy. Unfortunately, the patient died from multiple metastases of the left adrenal gland and brain 26 months after the surgery. The prognosis of small cell carcinoma of the pancreas is extremely poor. Multimodal treatment such as chemotherapy, radiotherapy, and curative operation are required for long-term survival.

• Authors: Hiroto Sannomiya, Tatsuya Okamoto, Shintaro Ryu, Jun Ichikawa, Nobuhiko Koreeda, Yuki Shin, Ippei Yamana, Keisuke Sato, Yasushi Yoshida, Tomoaki Noritomi, Takahisa Yoshida, Keiji Hirata
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 46 Issue 13 Pg. 2312-2314 (Dec 2019) ISSN: 0385-0684 [Print] Japan
• PMID: 32156915 (Publication Type: Case Reports, Journal Article)

Chemical References

• Irinotecan
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Small Cell (diagnostic imaging, drug therapy)
• Cisplatin
• Humans
• Irinotecan
• Male
• Middle Aged
• Pancreatic Neoplasms (diagnostic imaging, drug therapy)
• Positron Emission Tomography Computed Tomography