A case of MOG encephalomyelitis with T- cell lymphoma.

Abstract

BACKGROUND:

Myelin oligodendrocyte glycoprotein immunoglobulin-G (IgG)-associated encephalomyelitis (MOG-EM) is a distinct inflammatory demyelinating disease. We present an unusual MOG-EM cases with concomitant T-cell lymphoma.

CASE REPORT:

A 38-year-old Caucasian male presented with bilateral optic neuritis and multifocal transverse myelitis. He tested positive for MOG-IgG1 and his neurologic symptoms improved with high dose steroid treatment. Six months after his first MOG-EM symptoms, he developed ulcerative skin lesions on his leg and was diagnosed with primary cutaneous γδ T-cell lymphoma. The immunohistochemistry study, performed on his cancer tissue, was negative for MOG.

CONCLUSION:

Diagnosis of MOG-EM can be considered in patients with concomitant hematologic malignancy, which might be associated with the dysregulated adaptive immunity rather than the direct presentation of the onconeural antigen by cancer. Further studies need to be conducted for the risks and incidence of malignancy in a larger cohort of MOG-EM.

• Authors: Young Nam Kwon, Jiwon Koh, Yoon Kyung Jeon, Jung-Joon Sung, Sung-Hye Park, Sung-Min Kim
• Journal: Multiple sclerosis and related disorders (Mult Scler Relat Disord) Vol. 41 Pg. 102038 (Jun 2020) ISSN: 2211-0356 [Electronic] Netherlands
• PMID: 32155461 (Publication Type: Case Reports)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• MOG protein, human
• Myelin-Oligodendrocyte Glycoprotein

Topics

• Adult
• Encephalomyelitis (diagnosis, immunology)
• Humans
• Lymphoma, T-Cell (diagnosis)
• Male
• Myelin-Oligodendrocyte Glycoprotein (immunology)
• Myelitis, Transverse (diagnosis)
• Optic Neuritis (diagnosis)