Effect of Transplantation of Neural Stem and Progenitor Cells on Memory in Animals with Alzheimer's Type Neurodegeneration.

Abstract

The effects of systemic and intracerebral transplantation of human fetal neural stem and progenitor cells were studied on the model of olfactory bulbectomy in mice with developing signs of sporadic Alzheimer's disease. It was found that transplantation of these cells at certain stages of disease development contributed to improvement of spatial memory and preservation of hippocampal neurons in these animals.

• Authors: R A Poltavtseva, A N Samokhin, N V Bobkova, M A Alexandrova, G T Sukhikh
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 168 Issue 4 Pg. 589-596 (Feb 2020) ISSN: 1573-8221 [Electronic] United States
• PMID: 32152851 (Publication Type: Journal Article)

Topics

• Administration, Intravenous
• Alzheimer Disease (pathology, physiopathology, therapy)
• Animals
• Cell Differentiation
• Disease Models, Animal
• Fetal Stem Cells (cytology, physiology, transplantation)
• Fetus
• Hippocampus (pathology, physiopathology)
• Humans
• Injections, Intralesional
• Maze Learning (physiology)
• Mice
• Mice, Inbred Strains
• Neural Stem Cells (cytology, physiology, transplantation)
• Neurogenesis (physiology)
• Neurons (cytology, physiology)
• Olfactory Bulb (surgery)
• Primary Cell Culture
• Spatial Memory (physiology)
• Spheroids, Cellular (cytology, physiology, transplantation)
• Stem Cell Transplantation (methods)
• Transplantation, Heterologous