We prospectively analysed 546 AMI patients aged ≥80 years undergoing PCI from 2009 to 2017.
Frailty was classified based on impairment in walking (unassisted, assisted, and wheelchair/non-ambulatory), cognition (normal, mildly impaired, moderately to severely impaired), and basic
activities of daily living. Impairment in each domain was scored as 0, 1, or 2, and patients were categorized into the following three groups based on total score: no
frailty (0), mild
frailty (1-2), moderate-to-severe
frailty (≥3). The median follow-up period was 589 days. Of the 546 patients, 27.8% were frail (mild or moderate-to-severe), and this proportion significantly increased to 35.5% at discharge (P < 0.001). Compared to non-frail patients, frail patients were older, less likely to be male, and had a higher rate of advanced Killip class. Major
bleeding (no
frailty, 9.6%; mild
frailty, 16.9%; moderate-to-severe
frailty, 31.8%; P < 0.001) and in-hospital mortality (no
frailty, 8.4%; mild
frailty, 15.4%; moderate-to-severe
frailty, 27.3%; P < 0.001) increased as
frailty worsened. After adjusting for confounders,
frailty was independently associated with higher mid-term all-cause mortality (hazard ratio, 1.81; 95% confidence interval, 1.23-2.65; P = 0.002).
CONCLUSION: