Sepsis can cause
septic shock, multiple organ dysfunction and even death. The combination of different blood purification would be the certain trend in the treatment of
sepsis.This study was to evaluate the clinical effects of
hemoperfusion (HP) combined with pulse high volume
hemofiltration (PHVHF) on
septic shock.Thirty cases were involved in this study and were randomly divided into two groups: HP and PHVHF group (n = 15) and CVVH (
continuous veno-venous hemofiltration) group (n = 15). Acute physiology and chronic health evaluation (APACHE) II scores, sequential organ failure assessment (SOFA) scores as well as biochemical changes were measured before and after the treatment. The levels of
IL-6,
IL-10, and TNF-α in plasma were assessed by ELISA before and
after treatment for 2 and 24 h. The
norepinephrine doses were also analyzed. The 28-day mortalities in both groups were also compared.In both groups, body temperature (BT), respiratory rate (RR), white blood cells (WBC),
C-reactive protein (CRP),
Procalcitonin (PCT),
lactic acid, serum
creatinine, APACHE II scores and SOFA scores decreased after
hemofiltration (P < .05). The HP&PHVHF group was superior to the CVVH group in CRP, APACHE II score (P < .01), and heart rate (HR), WBC, PCT, SOFA (P < .05). The doses of
norepinephrine were also decreased
after treatment (P < .01), with more reduction in the HP&PHVHF group (P < .05). After 24 h of treatment, the levels of
IL-6,
IL-10, and TNF-α decreased in both groups (P < .05), and the decrease was more significant in HP&PHVHF group (P < .05). In combined group, after 2 h of hemoperfison, there was a significant reduction in these inflammatory factors (P < .01). Combined therapy group's mortality was 26.7%, while CVVH group's was 40%.HP combined with PHVHF has a significant effect on
septic shock and can be an important
therapy for
septic shock.