Abstract | OBJECTIVE: METHODS: In the randomized, double-blind, placebo-controlled, 6-week trial, 97 patients with BPSD were allocated to receive 250-1500 mg/day of sodium benzoate or placebo. Cognitive function was measured by the Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog) and behavioral and psychological symptoms were mainly measured by Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). DAAO level, amino acids ( L-serine, D- serine, L-alanine, and D- alanine, glycine), and two antioxidants ( catalase, superoxide dismutase) were assayed in peripheral blood. RESULTS: After benzoate treatment, DAAO inhibition was correlated with ADAS-cog decrease (p = 0.034), while baseline DAAO level was correlated with baseline BEHAVE-AD score. Multiple linear regression analyses showed that cognitive improvement after benzoate treatment was correlated with DAAO decrease, female gender, younger age, BMI, baseline BPSD severity, and antipsychotic use. CONCLUSION: The finding suggests that sodium benzoate may have potential to benefit cognitive function in a fraction of BPSD patients after 6 weeks of treatment. Of note, the precision medicine approach may be helpful for identifying individuals who could respond to benzoate. More studies are warranted to confirm the preliminary findings. TRIAL REGISTRATION: The trial was registered online (https://clinicaltrials.gov/ct2/show/NCT02103673).
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Authors | Chieh-Hsin Lin, Hui-Ting Yang, Ping-Kun Chen, Shi-Heng Wang, Hsien-Yuan Lane |
Journal | Neuropsychiatric disease and treatment
(Neuropsychiatr Dis Treat)
Vol. 16
Pg. 509-518
( 2020)
ISSN: 1176-6328 [Print] New Zealand |
PMID | 32110025
(Publication Type: Journal Article)
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Copyright | © 2020 Lin et al. |