Abstract | PURPOSE: PATIENTS AND METHODS: One hundred and seventeen Patients with AGC who received NAC followed by R0 resection between January 2006 and December 2012 were included. Tumor volumes were quantified using OsiriX software. The volume reduction rate (VRR) was calculated as follows: VRR = [(pre- chemotherapy total volume) - (post- chemotherapy total volume)]/(pre- chemotherapy total volume) × 100%. The optimal cut-off VRR for differentiating favorable from unfavorable prognosis was determined by receiver operating characteristic (ROC) analysis. Overall survival was calculated using Kaplan-Meier analysis and values were compared using the Log-rank test. Multivariate analysis was determined by the Cox proportional regression model. RESULTS: The optimal cut-off VRR was 31.95% according to ROC analysis, with a sensitivity of 70.4% and a specificity of 71.7%. Based on the cut-off VRR, patients were divided into the VRR-High (VRR ≥ 31.95%, n = 63) and VRR-Low (VRR < 31.95%, n = 54) groups. The VRR-Low group exhibited a worse prognosis than that of the VRR-High group (HR, 2.85; 95% CI, 1.69-4.82, P < 0.001), with 3-year survival rates of 40.7% and 79.4%, and 5-year survival rates of 31.5% and 63.5%, respectively. CONCLUSION: CT volumetry is a feasible and reliable method for assessing the tumor response to NAC in patients with AGC.
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Authors | Chao Chen, Hao Dong, Chunhui Shou, Xiaoxiao Shi, Qing Zhang, Xiaosun Liu, Kankai Zhu, Baishu Zhong, Jiren Yu |
Journal | Cancer management and research
(Cancer Manag Res)
Vol. 12
Pg. 759-768
( 2020)
ISSN: 1179-1322 [Print] New Zealand |
PMID | 32099471
(Publication Type: Journal Article)
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Copyright | © 2020 Chen et al. |