Cholesterol mass efflux capacity and risk of peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis.

Abstract

BACKGROUND AND AIMS:

We aimed to assess the relationship of HDL (high-density lipoprotein)-mediated cholesterol mass efflux capacity (CMEC) with risk of incident peripheral artery disease (PAD).

METHODS:

CMEC was measured in 1458 Multi-Ethnic Study of Atherosclerosis participants between 2000 and 2002 as part of a case-control study matched for incident cardiovascular disease and progression of carotid plaque by ultrasound. Incident clinical PAD, adjudicated on the basis of a positive history for the presence of disease-related symptoms or treatment, was ascertained through 2015 in 1419 individuals without clinical PAD at baseline. Subclinical PAD, defined as an ankle-brachial index (ABI) ≤1.0, was assessed among 1255 individuals with a baseline ABI >1.0 and at least one follow-up ABI measurement 3-10 years later. Cox proportional hazards and relative risk regression modeling per SD increment of CMEC were used to determine the association of CMEC with clinical and subclinical PAD, respectively.

RESULTS:

There were 38 clinical PAD and 213 subclinical PAD events that occurred over a mean follow-up of 6.0 and 6.5 years respectively. After adjustment for age, gender, and race, higher CMEC levels were not associated with clinical PAD (hazard ratio 1.25; 95% CI 0.89, 1.75) or subclinical PAD (risk ratio 1.02; 95% CI, 0.94, 1.11).

CONCLUSIONS:

These findings suggest that HDL-mediated cholesterol efflux is not significantly associated with incident clinical and subclinical PAD.

• Authors: Parveen K Garg, Neal W Jorgensen, Robyn L McClelland, Matthew Allison, James H Stein, Laurent Yvan-Chavret, Alan R Tall, Steven Shea
• Journal: Atherosclerosis (Atherosclerosis) Vol. 297 Pg. 81-86 (03 2020) ISSN: 1879-1484 [Electronic] Ireland
• PMID: 32097805 (Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Cholesterol, HDL

Topics

• Aged
• Aged, 80 and over
• Ankle Brachial Index
• Biomarkers (blood)
• Case-Control Studies
• Cholesterol, HDL (blood)
• Female
• Humans
• Incidence
• Macrophages (metabolism)
• Male
• Middle Aged
• Peripheral Arterial Disease (blood, diagnosis, ethnology)
• Prognosis
• Risk Assessment
• Risk Factors
• THP-1 Cells
• Time Factors
• United States (epidemiology)