Impaired HDL cholesterol efflux capacity in systemic lupus erythematosus patients is related to subclinical carotid atherosclerosis.

Abstract

OBJECTIVES:

Lipid profiles appear to be altered in SLE patients due to disease activity and inflammation. Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein cholesterol to accept cholesterol from macrophages. CEC has been linked to cardiovascular events in the general population and is impaired in SLE patients. The aim of this study was to establish whether CEC is related to subclinical carotid atherosclerosis in SLE patients.

METHODS:

The present report is of a cross-sectional study that encompassed 418 individuals: 195 SLE patients and 223 controls. CEC, using an in vitro assay, and lipoprotein serum concentrations were assessed in patients and controls. Carotid intima-media thickness and carotid plaques were evaluated in SLE patients. A multivariable analysis was performed to study the relationship of CEC to SLE-related data, lipid profile and subclinical carotid atherosclerosis.

RESULTS:

CEC was downregulated in SLE patients [8.1  (4.2) % vs 16.9 (10.4) %, P = 0.004). This occurred independently of traditional cardiovascular risk factors, statin use or other variations in the lipid profile related to the disease. Traditional cardiovascular risk factors, both in patients and controls, and SLE-related data such as activity, severity or damage were not associated with CEC. After multivariable regression analysis including lipid profile-related molecules, CEC was inversely and independently associated with the presence of carotid plaques in SLE patients [odds ratio 0.87 (95% CI: 0.78, 0.97), P = 0.014].

CONCLUSION:

CEC is impaired in SLE patients independently of other inflammation-related lipid profile modifications that occur during the disease. CEC is associated with carotid plaques in SLE patients.

• Authors: Hiurma Sánchez-Pérez, Juan Carlos Quevedo-Abeledo, Laura de Armas-Rillo, Íñigo Rua-Figueroa, Beatriz Tejera-Segura, Estefanía Armas-González, José David Machado, Jose A García-Dopico, Alejandro Jimenez-Sosa, Carlos Rodríguez-Lozano, Federico Díaz-González, Miguel A González-Gay, Iván Ferraz-Amaro
• Journal: Rheumatology (Oxford, England) (Rheumatology (Oxford)) Vol. 59 Issue 10 Pg. 2847-2856 (10 01 2020) ISSN: 1462-0332 [Electronic] England
• PMID: 32065639 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: [email protected].

Chemical References

• Cholesterol, HDL
• Lipids
• Cholesterol

Topics

• Carotid Artery Diseases (metabolism, pathology)
• Carotid Intima-Media Thickness
• Case-Control Studies
• Cholesterol (metabolism)
• Cholesterol, HDL (metabolism)
• Cross-Sectional Studies
• Down-Regulation
• Female
• Humans
• Lipids (blood)
• Lupus Erythematosus, Systemic (metabolism)
• Macrophages (metabolism)
• Male
• Middle Aged
• Plaque, Atherosclerotic (metabolism)
• Regression Analysis