Abstract | INTRODUCTION: The assessment of bone marrow thrombopoietic activity in patients with thrombocytopenia is necessary to achieve an accurate diagnosis and administer effective treatment. We evaluated the discriminatory power of the immature platelet fraction (IPF) in differentiating hyperdestructive/consumptive thrombocytopenia from hypoproductive thrombocytopenia and its potential use as a predictive marker for platelet recovery. METHODS: RESULTS: The platelet distribution width, mean platelet volume, platelet large cell ratio, IPF, and absolute immature platelet count ( AIPC) were significantly higher in the hyperdestructive/consumptive thrombocytopenia group than in the hypoproductive thrombocytopenia group (Pā<ā.001). The IPF showed the highest difference between the two patient groups (200%). Receiver operating characteristics analysis that showed the IPF had the largest area under the curve among all the platelet indices analyzed; its cut-off value was 2.3%. The IPF decreased 3 to 4 days in advance of platelet count elevation in patients with ITP, whereas the delta AIPC increased 3 days in advance. Furthermore, the IPF and delta AIPC increased 5.5 days and 8.5 days, respectively, before platelet counts increased up to 130.0ā×ā10/L in cancer patients receiving chemotherapy. CONCLUSION: These data demonstrated that the IPF and delta AIPC are both excellent indicators of the etiology of thrombocytopenia and predictive markers for platelet recovery.
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Authors | Kibum Jeon, Miyoung Kim, Jiwon Lee, Jee-Soo Lee, Han-Sung Kim, Hee Jung Kang, Young Kyung Lee |
Journal | Medicine
(Medicine (Baltimore))
Vol. 99
Issue 7
Pg. e19096
(Feb 2020)
ISSN: 1536-5964 [Electronic] United States |
PMID | 32049816
(Publication Type: Journal Article, Observational Study)
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Chemical References |
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Topics |
- Adult
- Aged
- Anemia, Aplastic
(blood, complications, diagnosis)
- Biomarkers
(blood)
- Case-Control Studies
- Female
- Humans
- Male
- Mean Platelet Volume
- Middle Aged
- Neoplasms
(complications)
- Platelet Count
- Predictive Value of Tests
- Purpura, Thrombocytopenic, Idiopathic
(blood, diagnosis)
- ROC Curve
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