Abstract | BACKGROUND: PURPOSE: STUDY DESIGN: Systematic review and meta-analysis. METHODS: MEDLINE, Embase, Web of Science, and Scopus databases were searched for clinical trials reporting pain and joint function with the visual analog scale, Patient-Rated Tennis Elbow Evaluation, and Disabilities of the Arm, Shoulder and Hand in patients with lateral epicondylitis. The meta-analysis was conducted with a random effects model and generic inverse variance method. Heterogeneity was tested with the I2 statistic index. RESULTS: A total of 15 RCTs included in this meta-analysis revealed a significant improvement in pain (mean difference, 3.61 cm [95% CI, 2.29-4.92 cm]; P < .00001; I2 = 88%; visual analog scale) and function (mean difference, 25.65 [95% CI, 13.30-37.99]; P < .0001; I2 = 82%; Patient-Rated Tennis Elbow Evaluation / Disabilities of the Arm, Shoulder and Hand) after NS injection (≥6 months). CONCLUSION: NS injections yielded a statistically significant and clinically meaningful improvement in pain and functional outcomes in patients with lateral epicondylitis. New research should focus on better methods to diminish the potential confounders that could lead to this effect because NS injections could mask the real effect of an active therapeutic intervention in RCT. REGISTRATION: CRD42019127547 (PROSPERO).
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Authors | Carlos Alberto Acosta-Olivo, Juan Manuel Millán-Alanís, Luis Ernesto Simental-Mendía, Neri Álvarez-Villalobos, Félix Vilchez-Cavazos, Víctor Manuel Peña-Martínez, Mario Simental-Mendía |
Journal | The American journal of sports medicine
(Am J Sports Med)
Vol. 48
Issue 12
Pg. 3094-3102
(10 2020)
ISSN: 1552-3365 [Electronic] United States |
PMID | 32045280
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Chemical References |
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Topics |
- Humans
- Injections, Intra-Articular
- Pain Measurement
- Randomized Controlled Trials as Topic
- Saline Solution
(administration & dosage, therapeutic use)
- Tennis Elbow
(drug therapy)
- Treatment Outcome
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