Abstract | BACKGROUND: METHODS: Data from patients with primary TNBC consecutively diagnosed at the Breast Disease Center of Peking University First Hospital from 2008 to 2014 were retrieved, and the cases with RT in the breast after NAC were enrolled. TILs subtypes in RT were observed by double-staining immunohistochemistry, and counted with the median TILs value per square millimeter as the cut-off to define high versus low TILs density in each subtype. The relationships between the TIL density of each subgroup and the clinicopathological characteristics of the RT after NAC patients were analyzed by Fisher exact test. Disease-free survival (DFS) and overall survival (OS) were analyzed by the Kaplan-Meier method and log-rank statistics. RESULTS: A total of 37 eligible patients were included in this study, and the median follow-up period was 50 months (range 17-106 months). There was no significant correlation between the infiltrate density of CD4, CD8, CD20, and CD68 lymphocytes and clinic-pathological characteristics. Significantly better prognosis was observed in patients with high CD4-TILs (DFS: P = 0.005, OS: P = 0.021) and high CD8-TILs (DFS: P = 0.018) and low CD20-TILs (OS: P = 0.042). Further analysis showed that patients with CD4/CD20 ratio greater than 1 (DFS: P = 0.001, OS: P = 0.002) or CD8/CD20 ratio greater than 1 (DFS: P = 0.009, OS: P = 0.022) had a better prognosis. CONCLUSIONS: Subtypes of TILs in RT is a potential predictive biomarker of survival in TNBC patients after NAC.
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Authors | Yu-Ge Bai, Guo-Xuan Gao, Hong Zhang, Shuang Zhang, Yin-Hua Liu, Xue-Ning Duan, Ling Xu |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 133
Issue 5
Pg. 552-560
(Mar 05 2020)
ISSN: 2542-5641 [Electronic] China |
PMID | 32044815
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD20
- Biomarkers
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Topics |
- Adult
- Antigens, CD20
(metabolism)
- Biomarkers
(metabolism)
- CD4-Positive T-Lymphocytes
(metabolism)
- CD8-Positive T-Lymphocytes
(metabolism)
- Disease-Free Survival
- Female
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Lymphocytes, Tumor-Infiltrating
(immunology, metabolism, physiology)
- Neoadjuvant Therapy
- Prognosis
- Triple Negative Breast Neoplasms
(immunology, metabolism, pathology)
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