Specific chemical reactions only happen in the
tumor region and produce abundant special chemicals to in situ trigger a train of biological and pathological effects that may enable
tumor-specific curative effects to treat
cancer without causing serious side effects on normal cells or organs. Chemodynamic
therapy (CDT) is a rising tactic for
cancer therapy, which induces
cancer cell death via a localized Fenton reaction. However, the
tumor therapeutic effect is limited by the efficiency of the chemical reaction and relies heavily on the catalyst. Here, we constructed hollow porous
carbon coated FeS2 (HPFeS2@C)-based nanocatalysts for triple-enhanced CDT.
Tannic acid was encapsulated in HPFeS2@C for reducing Fe3+ to Fe2+, which had a better catalytic activity to accelerate the Fenton reaction. Afterward,
glucose oxidase (GOx) in nanocatalysts could consume
glucose in the tumor microenvironment and in situ synchronously produce H2O2, which could improve Fenton reaction efficiency. Meanwhile, the consumption of
glucose could lead to the
starvation effect for
cancer starvation therapy. The photothermal effects of HPFeS2@C could generate heat, which further sped up the Fenton process and implemented synergetic
photothermal therapy/
starvation therapy/CDT. The biodistribution of nanoparticles was investigated by multimodal magnetic resonance, ultrasound, and photoacoustic imaging. These nanocatalysts could trigger the catalytic Fenton reaction at a high degree, which might provide a good paradigm for nanocatalytic
tumor therapy.