Glucose Oxidase-Instructed Traceable Self-Oxygenation/Hyperthermia Dually Enhanced Cancer Starvation Therapy.

Abstract

Cancer theranostics based on glucose oxidase (GOx)-induced starvation therapy has got more and more attention in cancer management. Herein, GOx armed manganese dioxide nanosheets (denoted as MNS-GOx) were developed as cancer nanotheranostic agent for magnetic resonance (MR)/photoacoustic (PA) dual-modal imaging guided self-oxygenation/hyperthermia dually enhanced starvation cancer therapy. The manganese dioxide nanomaterials with different morphologies (such as nanoflowers, nanosheets and nanowires) were synthesized by a biomimetic approach using melanin as a biotemplate. Afterwards, the manganese dioxide nanosheets (MNS) with two sides and large surface area were selected as the vehicle to carry and deliver GOx. The as-prepared MNS-GOx can perform the circular reaction of glucose oxidation and H2O2 decomposition for enhanced starvation therapy. Moreover, the catalytic activity of GOx could be further improved by the hyperthermia of MNS-GOx upon near-infrared laser irradiation. Most intriguingly, MNS-GOx could achieve "turn-on" MR imaging and "turn-off" PA imaging simultaneously. The theranostic capability of MNS-GOx was evaluated on A375 tumor-bearing mice with all tumor elimination. Our findings integrated molecular imaging and starvation-based synergistic cancer therapy, which provided a new platform for cancer nanotheranostics.

• Authors: Ting He, Han Xu, Yifan Zhang, Shijian Yi, Run Cui, Shaojun Xing, Chaoliang Wei, Jing Lin, Peng Huang
• Journal: Theranostics (Theranostics) Vol. 10 Issue 4 Pg. 1544-1554 ( 2020) ISSN: 1838-7640 [Electronic] Australia
• PMID: 32042321 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The author(s).

Chemical References

• Manganese Compounds
• Melanins
• Oxides
• Hydrogen Peroxide
• Glucose Oxidase
• manganese dioxide

Topics

• Animals
• Cell Line, Tumor
• Glucose Oxidase (pharmacology)
• Hydrogen Peroxide
• Hyperthermia (metabolism)
• Hyperthermia, Induced (methods)
• Infrared Rays (therapeutic use)
• Magnetic Resonance Imaging (methods)
• Manganese Compounds
• Melanins (metabolism)
• Mice
• Mice, Nude
• Molecular Imaging (methods)
• Multimodal Imaging (methods)
• Nanoparticles
• Neoplasms (diagnostic imaging, metabolism, pathology, therapy)
• Oxides
• Photoacoustic Techniques (methods)
• Photothermal Therapy (methods)
• Starvation (chemically induced)
• Theranostic Nanomedicine (methods, statistics & numerical data)